RIOK3

Across TCGA cell cohorts, RIOK3 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIOK3-associated genes across cancer lineages are MT4, TBX22, and SSMEM1. Each is linked with RIOK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIOK3-to-partner and partner-to-RIOK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT4 grouped by RIOK3-low versus RIOK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOK3→partner) and Y-score (partner→RIOK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MT4 →	+2.587	+3.556	<.001	.007	3	1
LARGE_INTESTINE	TBX22 →	+0.030	+3.632	<.001	.003	3	1
LARGE_INTESTINE	SSMEM1 →	+0.025	+3.766	.001	.004	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1
LARGE_INTESTINE	S100G →	+1.372	+3.688	<.001	.002	3	1
LARGE_INTESTINE	TFDP3 →	+0.033	+4.518	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MT4 by RIOK3 expression — LARGE_INTESTINE

Explore this box plot interactively →