RIOK2

Across TCGA patient cohorts, RIOK2 mutation is significantly associated with the RNA expression of many other genes, with 2,051 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIOK2-associated genes across cancer lineages are MIR4478, SEPTIN14P19, and XACT. Each is linked with RIOK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIOK2-to-partner and partner-to-RIOK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4478 grouped by RIOK2-low versus RIOK2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOK2→partner) and Y-score (partner→RIOK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4478 →	+1.085	+3.996	<.001	.005	3	3
UCEC	SEPTIN14P19 →	+0.015	+3.245	<.001	.003	3	2
LUSC	XACT →	+0.339	+4.211	<.001	.009	3	2
LUSC	MIR3130-2 →	+0.692	+4.475	<.001	.005	3	2
SKCM	LINC02841 →	+0.031	+5.421	<.001	.001	3	2
HNSC	CBX3P8 →	+0.089	+6.221	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,051 associations by consensus.

MIR4478 by RIOK2 expression — CESC

Explore this box plot interactively →