RIOK1

Across TCGA patient cohorts, RIOK1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIOK1-associated genes across cancer lineages are eEF2, A-Raf_pS299, and ERK2. Each is linked with RIOK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIOK1-to-partner and partner-to-RIOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RIOK1-low versus RIOK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOK1→partner) and Y-score (partner→RIOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.403	+2.321	.007	.034	3	1
UCEC	A-Raf_pS299 →	-0.195	-2.321	<.001	.033	3	1
UCEC	ERK2 →	+0.232	+2.222	.004	.011	3	1
UCEC	FoxM1 →	+0.243	+1.700	.026	.044	3	1
UCEC	FOXO3a_pS318_S321 →	-0.167	-2.105	.001	.017	3	1
UCEC	ACVRL1 →	-0.168	-3.150	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

eEF2 by RIOK1 expression — UCEC

Explore this box plot interactively →