RIOK1

Across TCGA cell cohorts, RIOK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,130 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RIOK1-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, Maturation of SSU-rRNA, and Maturation of 5.8S rRNA. Each is linked with RIOK1 in more than 19 cancer types. Because this analysis shows association rather than direction, both RIOK1-to-partner and partner-to-RIOK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by RIOK1-low versus RIOK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RIOK1→partner) and Y-score (partner→RIOK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of RNA export from nucleus →	+0.181	+0.902	<.001	<.001	3	20
BONE	Maturation of SSU-rRNA →	+0.146	+0.936	<.001	<.001	3	17
BONE	Maturation of 5.8S rRNA →	+0.156	+0.983	<.001	<.001	3	17
PANCREAS	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.128	+0.936	<.001	<.001	3	17
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.127	+0.799	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Nuclear pore complex assembly →	+0.158	+0.982	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,130 associations by consensus.

Negative regulation of RNA export from nucleus by RIOK1 expression — BONE

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