RIN3

Across TCGA patient cohorts, RIN3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIN3-associated genes across cancer lineages are Cyclin-B1, p21, and MEK1. Each is linked with RIN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIN3-to-partner and partner-to-RIN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RIN3-low versus RIN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIN3→partner) and Y-score (partner→RIN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.615	+3.459	.005	.005	3	3
SKCM	p21 →	-0.572	-3.000	.007	.035	3	2
UCEC	MEK1 →	+0.320	+2.000	.025	.010	3	2
UCEC	p27 →	+0.251	+3.700	.003	.001	3	2
UCEC	TFRC →	+0.447	+2.999	.032	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.855	+2.584	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Cyclin-B1 by RIN3 expression — UCEC

Explore this box plot interactively →