RIN2

Across TCGA pan-cancer cohorts, RIN2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated RIN2 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RIN2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RIN2 expression acts as an unfavorable survival marker.

HNSC, LUSC, and LUAD are the cancer types where RIN2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.247	0.690	<.001	42	view →
LUSC	DFS	Median	II,III,IV	0.079	0.750	<.001	18	view →
LUAD	OS	Median	All	0.236	0.812	.001	15	view →
LAML	DFS	Median	All	0.056	0.572	.001	12	view →
KIRP	OS	Median	All	0.135	0.703	.002	12	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	12	view →
BLCA	DFS	Median	All	0.180	0.598	.019	9	view →
ESCA	DFS	Median	All	0.133	0.536	.005	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LGG	OS	Median	All	0.306	0.799	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RIN2–HNSC (OS)

Open the HNSC breakdown →