RIMS4

Across TCGA patient cohorts, RIMS4 mutation is significantly associated with the RNA expression of many other genes, with 3,101 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIMS4-associated genes across cancer lineages are RN7SL134P, GPX6, and SKA1. Each is linked with RIMS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIMS4-to-partner and partner-to-RIMS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by RIMS4-low versus RIMS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMS4→partner) and Y-score (partner→RIMS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.115	+2.319	<.001	.001	3	3
READ	GPX6 →	+0.044	+5.653	<.001	.003	3	2
UCEC	SKA1 →	+0.877	+2.818	<.001	<.001	3	2
UCEC	EME1 →	+0.666	+2.332	<.001	<.001	3	2
UCEC	SLC34A2 →	-1.473	-1.915	<.001	.005	3	2
UCEC	LY6E →	-1.199	-3.796	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,101 associations by consensus.

RN7SL134P by RIMS4 expression — UCEC

Explore this box plot interactively →