RIMS2

Across TCGA patient cohorts, RIMS2 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIMS2-associated genes across cancer lineages are Caveolin-1, Bim, and MIG-6. Each is linked with RIMS2 in more than 4 cancer types. Because this analysis shows association rather than direction, both RIMS2-to-partner and partner-to-RIMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by RIMS2-low versus RIMS2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMS2→partner) and Y-score (partner→RIMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caveolin-1 →	-0.682	-2.700	.003	.004	3	5
LUAD	Bim →	+0.222	+1.054	.003	.027	3	4
LUSC	MIG-6 →	+0.084	+1.603	.011	.017	3	4
COAD	ASNS →	+0.370	+2.584	.001	.009	3	4
UCEC	S6_pS240_S244 →	+0.315	+1.777	.002	.001	3	4
STAD	TIGAR →	+0.285	+1.584	.025	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

Caveolin-1 by RIMS2 expression — STAD

Explore this box plot interactively →