RIMS2

Across TCGA cell cohorts, RIMS2 mutation is significantly associated with the RNA expression of many other genes, with 452 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RIMS2-associated genes across cancer lineages are MSANTD1, C2orf78, and PRORY. Each is linked with RIMS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RIMS2-to-partner and partner-to-RIMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSANTD1 grouped by RIMS2-low versus RIMS2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMS2→partner) and Y-score (partner→RIMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MSANTD1 →	+0.231	+3.584	.008	<.001	3	3
BLOOD_Leukemia	C2orf78 →	+0.067	+2.526	.005	.008	3	3
URINARY_TRACT	PRORY →	+0.257	+4.087	<.001	.009	3	2
BLOOD_Lymphoma	PATE1 →	+0.041	+3.736	.009	.009	3	2
BLOOD_Lymphoma	EFCAB3 →	+0.020	+3.736	.008	.009	3	2
LUNG_NSCLC_LUAD	BTG4 →	+0.440	+2.536	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 452 associations by consensus.

MSANTD1 by RIMS2 expression — LUNG_SCLC

Explore this box plot interactively →