RIMBP3

Across TCGA pan-cancer cohorts, RIMBP3 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated RIMBP3 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RIMBP3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RIMBP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, UVM, and KIRC are the cancer types where RIMBP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.729	0.532	<.001	93	view →
UVM	DFS	Quartile	All	0.342	0.794	<.001	84	view →
KIRC	DFS	Quartile	IV	0.772	0.204	.001	38	view →
BRCA	DFS	Tertile	All	0.937	0.965	.006	37	view →
STAD	OS	Tertile	All	0.732	0.558	.006	28	view →
CESC	OS	Tertile	IV	0.725	0.329	.021	26	view →
MESO	DFS	Median	All	0.172	0.298	.003	24	view →
LIHC	OS	Quartile	All	0.541	0.775	.005	20	view →
SKCM	DFS	Median	III,IV	0.446	0.165	.007	13	view →
THCA	OS	Quartile	II,III,IV	0.955	0.695	.015	11	view →
LUAD	DFS	Median	IV	0.344	0.624	.017	10	view →
BLCA	DFS	Quartile	All	0.544	0.670	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

RIMBP3–HNSC (DFS)

Open the HNSC breakdown →