RILPL2

Across TCGA patient cohorts, RILPL2 mutation is significantly associated with the RNA expression of many other genes, with 609 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RILPL2-associated genes across cancer lineages are SLC7A11, VIPAS39, and TIAM1. Each is linked with RILPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RILPL2-to-partner and partner-to-RILPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A11 grouped by RILPL2-low versus RILPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RILPL2→partner) and Y-score (partner→RILPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC7A11 →	+1.210	+3.459	<.001	.005	3	1
UCEC	VIPAS39 →	+0.446	+3.377	.007	.004	3	1
UCEC	TIAM1 →	-0.821	-3.459	.003	.005	3	1
UCEC	C1orf52 →	+0.432	+3.480	.007	.002	3	1
UCEC	KIAA1841 →	+0.657	+3.459	.001	.005	3	1
UCEC	C4orf36 →	+0.347	+3.470	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 609 associations by consensus.

SLC7A11 by RILPL2 expression — UCEC

Explore this box plot interactively →