RIC8A

Across TCGA pan-cancer cohorts, RIC8A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RIC8A data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher RIC8A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RIC8A expression acts as an unfavorable survival marker.

STAD, HNSC, and PRAD are the cancer types where RIC8A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.135	0.690	<.001	48	view →
HNSC	OS	Median	All	0.169	0.710	.008	18	view →
PRAD	DFS	Median	All	0.085	0.774	.006	6	view →
LIHC	DFS	Median	All	0.094	0.526	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RIC8A–STAD (OS)

Open the STAD breakdown →