RIC8A

Across TCGA pan-cancer cohorts, RIC8A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RIC8A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RIC8A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RIC8A expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where RIC8A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.598	0.848	<.001	67	view →
PDAC	DFS	Quartile	All	0.262	0.518	.017	22	view →
LSCC	DFS	Quartile	II,III,IV	0.616	1.000	.005	22	view →
LUAD	OS	Quartile	All	1.000	0.954	.034	3	view →
HNSC	DFS	Quartile	III,IV	0.889	0.333	.024	2	view →
GBM	OS	Quartile	All	0.620	0.943	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RIC8A–CCRCC (DFS)

Open the CCRCC breakdown →