RIC8A

Across TCGA patient cohorts, RIC8A RNA expression is significantly associated with the mutation status of many other genes, with 9,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC8A-associated genes across cancer lineages are NAV3, EGFR, and TTN. Each is linked with RIC8A in more than 4 cancer types. Because this analysis shows association rather than direction, both RIC8A-to-partner and partner-to-RIC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAV3 grouped by RIC8A-low versus RIC8A-high in STAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC8A→partner) and Y-score (partner→RIC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NAV3 →	+2.923	+0.298	<.001	.002	3	5
LGG	EGFR →	+2.366	+0.232	.002	.002	3	4
STAD	TTN →	+0.934	+0.173	<.001	.002	3	4
STAD	COL6A6 →	+2.427	+0.313	.001	.005	3	4
SKCM	TP53 →	+1.697	+0.272	<.001	<.001	3	4
UCEC	STAB2 →	+1.361	+0.229	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,725 associations by consensus.

NAV3 by RIC8A expression — STAD

Explore this box plot interactively →