RIC8A

Across TCGA patient cohorts, RIC8A mutation is significantly associated with the RNA expression of many other genes, with 1,055 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC8A-associated genes across cancer lineages are MIR3180-5, MIR3913-1, and RNU6-13P. Each is linked with RIC8A in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC8A-to-partner and partner-to-RIC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3180-5 grouped by RIC8A-low versus RIC8A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC8A→partner) and Y-score (partner→RIC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR3180-5 →	+0.274	+5.018	<.001	.004	3	2
KIRP	MIR3913-1 →	+0.367	+4.797	.002	.003	3	2
COAD	RNU6-13P →	+0.317	+4.308	.001	.009	3	2
COAD	LYPLA1P1 →	+0.341	+5.824	<.001	.001	3	2
COAD	MRPS21P5 →	+0.268	+4.308	.002	.009	3	2
COAD	FDPSP6 →	+0.160	+4.542	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,055 associations by consensus.

MIR3180-5 by RIC8A expression — BLCA

Explore this box plot interactively →