RIC8A

Across TCGA patient cohorts, RIC8A mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC8A-associated genes across cancer lineages are Gab2, JNK2, and Notch1. Each is linked with RIC8A in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC8A-to-partner and partner-to-RIC8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by RIC8A-low versus RIC8A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC8A→partner) and Y-score (partner→RIC8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.467	+3.000	.004	.036	2	2
UCEC	JNK2 →	+0.183	+3.026	.048	.018	3	1
UCEC	Notch1 →	+0.241	+3.331	<.001	.005	3	1
UCEC	Shc_pY317 →	-0.259	-2.584	<.001	.011	3	1
UCEC	STAT3_pY705 →	-0.393	-3.169	.001	.018	3	1
UCEC	Cyclin-B1 →	+0.608	+2.584	.020	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Gab2 by RIC8A expression — UCEC

Explore this box plot interactively →