RIC3

Across TCGA patient cohorts, RIC3 protein abundance is significantly associated with the RNA expression of many other genes, with 301 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RIC3-associated genes across cancer lineages are XBP1, HMOX1, and VWA8. Each is linked with RIC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC3-to-partner and partner-to-RIC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RIC3 versus XBP1 in GBM, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC3→partner) and Y-score (partner→RIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	XBP1 →	-0.551	-0.535	.002	<.001	3	1
GBM	HMOX1 →	-1.394	-0.600	.003	.006	3	1
GBM	VWA8 →	+0.498	+0.563	.001	.002	3	1
GBM	OGDH →	+0.420	+0.505	.003	.008	3	1
GBM	URGCP →	+0.461	+0.583	<.001	.003	3	1
GBM	STAG3L4 →	+0.452	+0.547	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 301 associations by consensus.

RIC3 vs XBP1 — GBM

Explore this scatter interactively →