RIC3

Across TCGA patient cohorts, RIC3 mutation is significantly associated with the RNA expression of many other genes, with 3,426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC3-associated genes across cancer lineages are RNU7-60P, MIR8058, and BRI3. Each is linked with RIC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIC3-to-partner and partner-to-RIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-60P grouped by RIC3-low versus RIC3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC3→partner) and Y-score (partner→RIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU7-60P →	+0.281	+4.146	<.001	.008	3	3
COAD	MIR8058 →	+0.937	+3.289	<.001	.008	3	3
SKCM	BRI3 →	+0.335	+2.144	.007	.009	3	2
UCEC	HDGFL2 →	+0.405	+3.343	.003	.005	3	2
UCEC	PUSL1 →	+0.577	+2.747	<.001	<.001	3	2
UCEC	EIF1 →	+0.311	+2.781	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,426 associations by consensus.

RNU7-60P by RIC3 expression — HNSC

Explore this box plot interactively →