RIC3

Across TCGA cell cohorts, RIC3 mutation is significantly associated with the mutation status of many other genes, with 2,389 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIC3-associated genes across cancer lineages are ARHGEF40, BCL9L, and TGM1. Each is linked with RIC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both RIC3-to-partner and partner-to-RIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGEF40 grouped by RIC3-low versus RIC3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC3→partner) and Y-score (partner→RIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARHGEF40 →	+2.942	+4.025	.009	.009	1	5
LARGE_INTESTINE	BCL9L →	+1.781	+3.602	.006	.006	1	4
LARGE_INTESTINE	TGM1 →	+3.137	+3.807	.001	.001	1	3
LUNG_NSCLC_LUAD	RBM15B →	+3.263	+3.851	.005	.005	1	3
LUNG_NSCLC_LUAD	ZNF865 →	+4.000	+4.303	.001	.001	1	3
LUNG_NSCLC_LUAD	H2AC17 →	+5.000	+4.187	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,389 associations by consensus.

ARHGEF40 by RIC3 expression — STOMACH

Explore this box plot interactively →