RIC1

Across TCGA pan-cancer cohorts, RIC1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RIC1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RIC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RIC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where RIC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.918	.009	38	view →
CCRCC	DFS	Quartile	All	0.776	0.263	.010	19	view →
LUAD	OS	Median	II,III,IV	1.000	0.807	.011	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RIC1–HNSC (DFS)

Open the HNSC breakdown →