RIC1

Across TCGA patient cohorts, RIC1 mutation is significantly associated with the RNA expression of many other genes, with 4,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC1-associated genes across cancer lineages are DRG1, MIR1268B, and TEX43. Each is linked with RIC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIC1-to-partner and partner-to-RIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRG1 grouped by RIC1-low versus RIC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC1→partner) and Y-score (partner→RIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DRG1 →	+0.297	+4.201	.001	<.001	3	3
STAD	MIR1268B →	+0.983	+3.722	.007	.006	3	3
UCEC	TEX43 →	+0.149	+1.301	.001	.005	3	3
UCEC	ACBD5 →	+0.386	+1.485	.005	.003	3	3
UCEC	HINT3 →	+0.354	+2.458	.007	.001	3	3
UCEC	VPS26A →	+0.393	+2.703	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,229 associations by consensus.

DRG1 by RIC1 expression — UCEC

Explore this box plot interactively →