RIC1

Across TCGA patient cohorts, RIC1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC1-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and Notch1. Each is linked with RIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC1-to-partner and partner-to-RIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by RIC1-low versus RIC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC1→partner) and Y-score (partner→RIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.145	-1.584	.005	.017	3	2
UCEC	Ku80 →	+0.182	+1.214	.013	.018	3	2
UCEC	Notch1 →	+0.118	+1.598	.007	.019	3	2
UCEC	p62 Lck ligand →	+0.287	+2.321	.004	.005	3	2
UCEC	Annexin-1 →	+0.367	+2.720	.025	.003	3	2
UCEC	ATM →	-0.581	-2.794	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK_pT183_Y185 by RIC1 expression — UCEC

Explore this box plot interactively →