RIBC2

Across TCGA patient cohorts, RIBC2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIBC2-associated genes across cancer lineages are p62 Lck ligand, XBP1, and Caspase-7-cleavedD198. Each is linked with RIBC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIBC2-to-partner and partner-to-RIBC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RIBC2-low versus RIBC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIBC2→partner) and Y-score (partner→RIBC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.439	+3.009	.014	.019	3	1
UCEC	XBP1 →	-0.267	-3.000	<.001	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+1.106	+3.019	<.001	.019	3	1
UCEC	EGFR_pY1068 →	-0.310	-3.169	.024	.020	1	1
UCEC	Tuberin →	+0.378	+3.169	.010	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by RIBC2 expression — UCEC

Explore this box plot interactively →