RHPN2

Across TCGA patient cohorts, RHPN2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHPN2-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with RHPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHPN2-to-partner and partner-to-RHPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RHPN2-low versus RHPN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHPN2→partner) and Y-score (partner→RHPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.266	+1.807	.016	.024	3	1
UCEC	EGFR_pY1068 →	-0.241	-1.847	.001	.007	3	1
UCEC	eIF4E →	+0.129	+2.087	.048	.005	3	1
UCEC	eIF4G →	+0.231	+2.807	.016	.002	3	1
UCEC	A-Raf_pS299 →	-0.103	-2.000	.005	.029	3	1
UCEC	ERK2 →	+0.146	+1.201	.014	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eEF2 by RHPN2 expression — UCEC

Explore this box plot interactively →