Across TCGA pan-cancer cohorts, RHOXF2B RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RHOXF2B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where RHOXF2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHOXF2B is over-expressed in tumor.
KICH and LIHC are the cancer types where RHOXF2B tumor–normal differential expression is most reproducible.