RHOXF1

Across TCGA patient cohorts, RHOXF1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOXF1-associated genes across cancer lineages are ER-alpha_pS118, VHL, and JNK2. Each is linked with RHOXF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOXF1-to-partner and partner-to-RHOXF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by RHOXF1-low versus RHOXF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOXF1→partner) and Y-score (partner→RHOXF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	+0.377	+2.820	.029	.035	3	1
UCEC	VHL →	-0.893	-3.000	.006	.036	3	1
UCEC	JNK2 →	+0.257	+3.331	.007	.005	2	1
UCEC	Ku80 →	+0.243	+2.817	.033	.036	2	1
UCEC	p38-MAPK →	-0.183	-3.149	.021	.019	2	1
UCEC	Beclin →	-0.100	-3.000	.028	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ER-alpha_pS118 by RHOXF1 expression — UCEC

Explore this box plot interactively →