RHOU

Across TCGA patient cohorts, RHOU mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOU-associated genes across cancer lineages are FOXO3a, Gab2, and P-Cadherin. Each is linked with RHOU in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOU-to-partner and partner-to-RHOU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by RHOU-low versus RHOU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOU→partner) and Y-score (partner→RHOU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.166	-2.986	.004	.037	3	1
UCEC	Gab2 →	+0.606	+3.000	.003	.037	1	1
UCEC	P-Cadherin →	-0.254	-2.986	.002	.037	1	1
UCEC	Shc_pY317 →	-0.198	-3.000	.023	.037	1	1
UCEC	VEGFR2 →	+0.364	+3.013	.034	.019	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FOXO3a by RHOU expression — UCEC

Explore this box plot interactively →