RHOT2

Across TCGA patient cohorts, RHOT2 mutation is significantly associated with the RNA expression of many other genes, with 1,527 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOT2-associated genes across cancer lineages are RNU6-1214P, MIR520C, and RNU6-730P. Each is linked with RHOT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RHOT2-to-partner and partner-to-RHOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1214P grouped by RHOT2-low versus RHOT2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOT2→partner) and Y-score (partner→RHOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1214P →	+0.396	+5.548	<.001	<.001	3	3
HNSC	MIR520C →	+0.306	+4.655	.008	.007	3	3
HNSC	RNU6-730P →	+0.405	+6.623	<.001	<.001	3	2
HNSC	TRAV7 →	+0.152	+5.182	<.001	.001	3	2
HNSC	TRAJ27 →	+0.601	+4.372	.002	.007	3	2
SKCM	RPL31P40 →	+0.054	+3.291	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,527 associations by consensus.

RNU6-1214P by RHOT2 expression — HNSC

Explore this box plot interactively →