RHOT2

Across TCGA patient cohorts, RHOT2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOT2-associated genes across cancer lineages are Rad50, Annexin-1, and Chk2_pT68. Each is linked with RHOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOT2-to-partner and partner-to-RHOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by RHOT2-low versus RHOT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOT2→partner) and Y-score (partner→RHOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.192	-1.584	.043	.036	3	2
UCEC	Annexin-1 →	+0.697	+3.604	<.001	.001	3	2
UCEC	Chk2_pT68 →	-0.161	-2.690	.027	.006	3	2
UCEC	C-Raf →	+0.177	+2.000	.001	.010	3	2
UCEC	14-3-3_beta →	-0.092	-2.973	.019	.035	3	1
UCEC	A-Raf_pS299 →	-0.130	-1.584	.005	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Rad50 by RHOT2 expression — UCEC

Explore this box plot interactively →