RHOT2

Across TCGA cell cohorts, RHOT2 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHOT2-associated genes across cancer lineages are FAM240A, PHOX2B, and SLC13A2. Each is linked with RHOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOT2-to-partner and partner-to-RHOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM240A grouped by RHOT2-low versus RHOT2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOT2→partner) and Y-score (partner→RHOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAM240A →	+0.070	+5.285	<.001	.003	3	2
BLOOD_Leukemia	PHOX2B →	+0.017	+3.365	<.001	.005	3	2
BLOOD_Myeloma	SLC13A2 →	+0.013	+4.807	<.001	.006	3	1
SKIN	SULT6B1 →	+0.123	+3.920	<.001	.005	3	1
OVARY	GHRH →	+0.296	+5.196	<.001	.005	3	1
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FAM240A by RHOT2 expression — STOMACH

Explore this box plot interactively →