RHOT1

Across TCGA patient cohorts, RHOT1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOT1-associated genes across cancer lineages are Rad50, ATM, and PCNA. Each is linked with RHOT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RHOT1-to-partner and partner-to-RHOT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by RHOT1-low versus RHOT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOT1→partner) and Y-score (partner→RHOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.159	-1.125	.030	.033	3	3
UCEC	ATM →	-0.513	-1.530	<.001	.004	3	3
UCEC	PCNA →	+0.204	+1.530	.001	.004	3	2
UCEC	PDCD4 →	-0.463	-1.502	.001	.025	3	2
UCEC	Annexin-1 →	+0.574	+3.087	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.076	-1.880	.012	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Rad50 by RHOT1 expression — UCEC

Explore this box plot interactively →