RHOT1

Across TCGA cell cohorts, RHOT1 mutation is significantly associated with the RNA expression of many other genes, with 401 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RHOT1-associated genes across cancer lineages are GSTT4, CRYGD, and ZC2HC1B. Each is linked with RHOT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOT1-to-partner and partner-to-RHOT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTT4 grouped by RHOT1-low versus RHOT1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOT1→partner) and Y-score (partner→RHOT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GSTT4 →	+0.013	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	CRYGD →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ZC2HC1B →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ZNF831 →	+0.013	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	C20orf85 →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CABS1 →	+0.100	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

GSTT4 by RHOT1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →