RHOJ

Across TCGA patient cohorts, RHOJ mutation is significantly associated with the RNA expression of many other genes, with 2,295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOJ-associated genes across cancer lineages are RNA5SP369, RPL22P18, and RPL32P28. Each is linked with RHOJ in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOJ-to-partner and partner-to-RHOJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by RHOJ-low versus RHOJ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOJ→partner) and Y-score (partner→RHOJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP369 →	+0.414	+2.193	<.001	.002	3	2
UCEC	RPL22P18 →	+0.231	+2.001	.002	.003	3	2
UCEC	RPL32P28 →	+0.246	+1.855	<.001	.003	3	2
LUSC	RNU6-1180P →	+0.491	+6.733	<.001	<.001	3	2
LUSC	LINC02647 →	+0.158	+7.102	<.001	<.001	3	2
LUSC	RN7SL702P →	+0.361	+5.337	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,295 associations by consensus.

RNA5SP369 by RHOJ expression — UCEC

Explore this box plot interactively →