RHOJ

Across TCGA patient cohorts, RHOJ mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOJ-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FASN. Each is linked with RHOJ in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOJ-to-partner and partner-to-RHOJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RHOJ-low versus RHOJ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOJ→partner) and Y-score (partner→RHOJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.264	-2.321	.010	.033	3	1
UCEC	eIF4E →	+0.176	+2.321	.043	.006	3	1
UCEC	FASN →	+0.448	+3.000	.005	.001	3	1
UCEC	Gab2 →	+0.492	+3.000	<.001	.001	3	1
UCEC	JNK2 →	+0.227	+2.321	.005	.006	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.367	-1.794	.048	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by RHOJ expression — UCEC

Explore this box plot interactively →