RHOJ

Across TCGA cell cohorts, RHOJ mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RHOJ-associated genes across cancer lineages are CPLX4, ACSM6, and CFHR2. Each is linked with RHOJ in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOJ-to-partner and partner-to-RHOJ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by RHOJ-low versus RHOJ-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOJ→partner) and Y-score (partner→RHOJ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.038	+3.766	<.001	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CPLX4 by RHOJ expression — LARGE_INTESTINE

Explore this box plot interactively →