RHOG

Across TCGA patient cohorts, RHOG mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOG-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and ERK2. Each is linked with RHOG in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOG-to-partner and partner-to-RHOG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RHOG-low versus RHOG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOG→partner) and Y-score (partner→RHOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-1.986	.007	.032	3	1
UCEC	eIF4G →	+0.311	+2.000	.026	.032	3	1
UCEC	ERK2 →	+0.222	+3.169	.010	.018	3	1
UCEC	Heregulin →	-0.113	-2.000	.042	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-2.321	.007	.034	3	1
UCEC	JNK2 →	+0.194	+2.000	.030	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by RHOG expression — UCEC

Explore this box plot interactively →