RHOF

Across TCGA pan-cancer cohorts, RHOF mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RHOF data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RHOF mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RHOF expression acts as an unfavorable survival marker, although some lineages such as OV and HNSC show a favorable association.

PDAC, OV, and HNSC are the cancer types where RHOF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.821	0.949	.003	43	view →
OV	DFS	Tertile	All	0.900	0.465	.009	16	view →
HNSC	DFS	Quartile	II,III,IV	0.915	0.570	.002	12	view →
LUAD	DFS	Tertile	All	0.686	0.322	.027	6	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →
LSCC	OS	Median	II,III,IV	0.612	0.884	.013	4	view →
UCEC	DFS	Tertile	All	0.826	0.971	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RHOF–PDAC (OS)

Open the PDAC breakdown →