RHOBTB2

Across TCGA patient cohorts, RHOBTB2 mutation is significantly associated with the RNA expression of many other genes, with 4,702 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOBTB2-associated genes across cancer lineages are MAK16, MZT1, and PDIK1L. Each is linked with RHOBTB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RHOBTB2-to-partner and partner-to-RHOBTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAK16 grouped by RHOBTB2-low versus RHOBTB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOBTB2→partner) and Y-score (partner→RHOBTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAK16 →	+0.537	+2.584	<.001	<.001	3	3
UCEC	MZT1 →	+0.584	+2.021	<.001	<.001	3	3
SKCM	PDIK1L →	+0.670	+3.221	.002	.009	3	3
SKCM	DDX18 →	+0.687	+3.706	.002	<.001	3	3
SKCM	HINT3 →	+0.686	+2.616	.002	.006	3	3
SKCM	MRPL19 →	+0.531	+3.719	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,702 associations by consensus.

MAK16 by RHOBTB2 expression — UCEC

Explore this box plot interactively →