RHOBTB2

Across TCGA cell cohorts, RHOBTB2 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHOBTB2-associated genes across cancer lineages are VWC2L, ELOA3CP, and CYP7A1. Each is linked with RHOBTB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOBTB2-to-partner and partner-to-RHOBTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by RHOBTB2-low versus RHOBTB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOBTB2→partner) and Y-score (partner→RHOBTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.008	+3.661	.001	.001	3	2
BLOOD_Leukemia	ELOA3CP →	+0.127	+3.526	<.001	.008	3	2
LARGE_INTESTINE	CYP7A1 →	+0.027	+2.994	.003	.006	3	2
BLOOD_Lymphoma	KRT71 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	OR52B2 →	+0.021	+4.714	.006	.002	3	1
BLOOD_Leukemia	CASQ2 →	+0.048	+2.926	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

VWC2L by RHOBTB2 expression — BLOOD_Leukemia

Explore this box plot interactively →