RHOBTB1

Across TCGA patient cohorts, RHOBTB1 mutation is significantly associated with the RNA expression of many other genes, with 3,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOBTB1-associated genes across cancer lineages are IFI27L1, PPP2R2D, and UFD1. Each is linked with RHOBTB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RHOBTB1-to-partner and partner-to-RHOBTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFI27L1 grouped by RHOBTB1-low versus RHOBTB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOBTB1→partner) and Y-score (partner→RHOBTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IFI27L1 →	+0.410	+1.378	<.001	.008	3	3
UCEC	PPP2R2D →	+0.285	+2.072	<.001	<.001	3	3
UCEC	UFD1 →	+0.405	+1.860	<.001	<.001	3	3
UCEC	LRRC59 →	+0.549	+1.818	<.001	<.001	3	3
UCEC	PSMD9 →	+0.301	+1.942	.002	.002	3	3
UCEC	BTBD6 →	+0.316	+3.021	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,383 associations by consensus.

IFI27L1 by RHOBTB1 expression — UCEC

Explore this box plot interactively →