RHOBTB1

Across TCGA patient cohorts, RHOBTB1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOBTB1-associated genes across cancer lineages are C-Raf, INPP4B, and JNK_pT183_Y185. Each is linked with RHOBTB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RHOBTB1-to-partner and partner-to-RHOBTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by RHOBTB1-low versus RHOBTB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOBTB1→partner) and Y-score (partner→RHOBTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.149	+2.115	<.001	<.001	3	3
UCEC	INPP4B →	-0.305	-2.169	.002	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.173	-1.807	.001	.024	3	2
UCEC	MEK1 →	+0.451	+2.115	<.001	<.001	3	2
UCEC	Akt_pT308 →	+0.403	+1.700	.042	.040	3	2
UCEC	PCNA →	+0.183	+1.765	.007	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

C-Raf by RHOBTB1 expression — UCEC

Explore this box plot interactively →