RHOBTB1

Across TCGA cell cohorts, RHOBTB1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHOBTB1-associated genes across cancer lineages are TAC1, LIPN, and TMEM196. Each is linked with RHOBTB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOBTB1-to-partner and partner-to-RHOBTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAC1 grouped by RHOBTB1-low versus RHOBTB1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOBTB1→partner) and Y-score (partner→RHOBTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TAC1 →	+0.192	+4.754	<.001	<.001	3	1
SKIN	LIPN →	+0.017	+4.562	<.001	<.001	3	1
BLOOD_Leukemia	TMEM196 →	+0.045	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR6N1 →	+0.272	+5.060	<.001	.001	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1
BLOOD_Leukemia	C16orf90 →	+0.031	+4.152	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TAC1 by RHOBTB1 expression — BLOOD_Myeloma

Explore this box plot interactively →