RHOB

Across TCGA pan-cancer cohorts, RHOB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RHOB data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RHOB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RHOB expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where RHOB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.919	1.000	.005	13	view →
UCEC	OS	Median	II,III,IV	0.666	1.000	.025	12	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.802	.016	9	view →
GBM	DFS	Median	All	0.844	0.650	.007	6	view →
HNSC	DFS	Tertile	III,IV	0.903	0.666	.014	6	view →
CCRCC	DFS	Tertile	All	0.906	0.484	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RHOB–LUAD (DFS)

Open the LUAD breakdown →