RHOB

Across TCGA pan-cancer cohorts, RHOB mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RHOB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RHOB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RHOB is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

HNSC, COAD, and CCRCC are the cancer types where RHOB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHOB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.685	<.001	11	view →
COAD	Male	III,IV	−0.679	<.001	9	view →
CCRCC	Male	All	+0.337	<.001	5	view →
LUAD	Female	II,III,IV	−0.218	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RHOB–HNSC

Open the HNSC breakdown →