RHEB

Across TCGA pan-cancer cohorts, RHEB mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RHEB’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RHEB mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RHEB is over-expressed in tumor.

LUAD, HNSC, and LSCC are the cancer types where RHEB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHEB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.442	<.001	9	view →
HNSC	Male	III,IV	+0.332	<.001	8	view →
LSCC	Male	II,III,IV	+0.225	<.001	6	view →
COAD	All	All	+0.193	.001	5	view →
OV	All	All	+0.717	<.001	2	view →
CCRCC	All	II,III,IV	+0.117	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RHEB–LUAD

Open the LUAD breakdown →