RHD

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RHD mutation is significantly associated with the RNA expression of many other genes, with 684 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHD-associated genes across cancer lineages are SNRNP25, SLBP, and ZNF367. Each is linked with RHD in more than 1 cancer types. Because this analysis shows association rather than direction, both RHD-to-partner and partner-to-RHD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHD→partner) and Y-score (partner→RHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSNRNP25 →+0.448+2.397.004.00332
UCECSLBP →+0.505+2.600.009.00632
UCECZNF367 →+0.744+3.343.001.00532
UCECZMYND19 →+0.544+3.032<.001<.00132
UCECCENPN →+0.743+3.021<.001<.00132
UCECREEP4 →+0.478+3.010.006<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 684 associations by consensus.

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