Across TCGA patient cohorts, RHD mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHD-associated genes across cancer lineages are MEK1, EGFR_pY1068, and INPP4B. Each is linked with RHD in more than 1 cancer types. Because this analysis shows association rather than direction, both RHD-to-partner and partner-to-RHD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHD→partner) and Y-score (partner→RHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.467	+3.321	.008	.010	3	2
UCEC	EGFR_pY1068 →	-0.295	-2.459	.015	.020	3	1
UCEC	INPP4B →	-0.327	-3.571	.036	.002	3	1
UCEC	JNK2 →	+0.198	+3.179	.039	.010	3	1
UCEC	Ku80 →	+0.254	+2.472	.025	.011	3	1
UCEC	STAT3_pY705 →	-0.384	-2.321	.002	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

RHD survival (RNA) · tumor vs normal (RNA) · all RHD data types