Across TCGA cell cohorts, RHD mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHD-associated genes across cancer lineages are OR2V1, CD300H, and RPE65. Each is linked with RHD in more than 1 cancer types. Because this analysis shows association rather than direction, both RHD-to-partner and partner-to-RHD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHD→partner) and Y-score (partner→RHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2V1 →	+0.042	+4.095	.004	.009	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
BLOOD_Leukemia	RPE65 →	+0.069	+4.060	<.001	.003	3	1
BLOOD_Leukemia	IAPP →	+0.037	+3.705	.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

RHD survival (RNA) · tumor vs normal (RNA) · all RHD data types