RHBDL3

Across TCGA patient cohorts, RHBDL3 mutation is significantly associated with the RNA expression of many other genes, with 2,018 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHBDL3-associated genes across cancer lineages are PRAMEF28P, PSMC1P3, and ANKRD33B-AS1. Each is linked with RHBDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHBDL3-to-partner and partner-to-RHBDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF28P grouped by RHBDL3-low versus RHBDL3-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDL3→partner) and Y-score (partner→RHBDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRAMEF28P →	+0.037	+5.584	<.001	.003	3	2
LIHC	PSMC1P3 →	+0.042	+4.100	<.001	.005	3	2
READ	ANKRD33B-AS1 →	+0.140	+5.681	<.001	.001	3	2
READ	RNU6-1169P →	+0.301	+4.421	<.001	.009	3	2
READ	RPL34P19 →	+0.227	+4.280	<.001	.007	3	2
READ	MIR5089 →	+1.029	+6.238	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,018 associations by consensus.

PRAMEF28P by RHBDL3 expression — GBM

Explore this box plot interactively →