RHBDL3

Across TCGA patient cohorts, RHBDL3 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHBDL3-associated genes across cancer lineages are ASNS, ATM, and 14-3-3_beta. Each is linked with RHBDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHBDL3-to-partner and partner-to-RHBDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RHBDL3-low versus RHBDL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDL3→partner) and Y-score (partner→RHBDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.518	+1.906	<.001	.015	3	2
UCEC	ATM →	-0.343	-1.700	.044	.042	3	2
UCEC	14-3-3_beta →	-0.093	-1.752	.014	.014	3	1
UCEC	A-Raf_pS299 →	-0.134	-2.700	.002	.006	3	1
UCEC	ERK2 →	+0.211	+3.584	.003	.002	3	1
UCEC	MEK1 →	+0.318	+2.321	.020	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ASNS by RHBDL3 expression — UCEC

Explore this box plot interactively →